Polynucleotides: The Next Generation of Skin Regeneration
- Emily
- 6 days ago
- 2 min read
In recent years, medical aesthetics has shifted away from simply treating lines and wrinkles, and towards restoring skin health at a cellular level.
What are polynucleotides?
Polynucleotides are naturally derived DNA fragments, typically sourced from purified salmon or trout DNA, which are highly biocompatible with human tissue. Rather than adding volume or freezing muscles, polynucleotides work by stimulating the skin’s own repair and regeneration processes.
Once injected into the skin, they act as bio-stimulators, encouraging fibroblasts (the cells responsible for collagen, elastin and skin structure) to function more effectively.
How do polynucleotides work?
Polynucleotides improve skin quality through several mechanisms:
Cell regeneration: They support tissue repair and renewal at a cellular level
Collagen stimulation: Encouraging improved firmness and elasticity over time
Improved hydration: By enhancing the skin’s ability to retain moisture
Anti-inflammatory effects: Helping calm stressed, sensitised or compromised skin
Improved skin texture and tone: Leading to healthier, more resilient skin overall
The result is skin that looks brighter, firmer, smoother and more rested — without altering facial structure or expression.
What areas can be treated?
Polynucleotides are incredibly versatile and are commonly used to treat:
Under-eye area (crepey skin, fine lines, poor skin quality)
Face (overall skin rejuvenation)
Neck and décolletage
Hands
Areas of skin laxity or thinning
They are particularly popular for delicate areas where traditional fillers may not be suitable.
Who is polynucleotide treatment suitable for?
Polynucleotides are ideal for patients who:
Want natural-looking results
Are concerned about skin quality rather than volume
Have thin, crepey or ageing skin
Are noticing early signs of ageing
Want a regenerative, preventative approach
Prefer subtle, progressive improvements
They are also a great option for patients who may not want dermal fillers, or who wish to complement other treatments such as skin boosters, microneedling or PRP.
How many treatments are needed?
For optimal results, polynucleotides are usually recommended as a course of treatments, often spaced a few weeks apart. Improvements continue gradually as the skin regenerates, with results becoming more noticeable over time rather than immediately.
Ready To Experience the Future of Skin Regeneration?
Polynucleotides represent a significant step forward in regenerative aesthetics. By working with the skin rather than against it, they offer a subtle, sophisticated approach to ageing - one that prioritises skin health, longevity and natural results.
As with all medical aesthetic treatments, a thorough consultation is essential to determine suitability and create a tailored treatment plan.
